5-甲基-2-氨基-3-硝基吡啶合成路线 （共 8 条）
反应条件
1: With sulfuric acid T=-10 - 20°C; 1 h; 2: With nitric acid in water T=55 - 60°C; 0.5 h; 3: With sodium hydroxide in water T=0°C; pH=9;
参考文献
CHEMOCENTRYX, INC.
Patent: WO2006/76644 A2, 2006 ;
Location in patent: Page/Page column 204 ;
WO 2006/076644 A2
参考文献
State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University and The University of Oregon, Eugene Oregon; The Regents of the University of California; ACEA Pharmaceuticals, Inc.
Patent: US5620978 A1, 1997 ;
US 5620978 A
反应条件
acetic acid in ethanol 15 h; Heating;
参考文献
Troschutz; Luckel
Archiv der Pharmazie, 1992 , vol. 325, # 12 p. 785 - 789
反应条件
in methanol 0.666667 h; Irradiation; Quantum yield;
参考文献
Sepiol, Jadwiga; Tomasik, Piotr
Acta Chimica Hungarica, 1986 , vol. 121, # 4 p. 333 - 338
反应条件
hydrazine in water T=110 - 120°C; 5 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 45, # 1 p. 115 - 118
反应条件
1: With hydrogen bromide in water T=-10 - 0°C; 2: With bromine; sodium nitrite in water T=-10 - 0°C; 1 h; 3: With sodium hydroxide in water T=0 - 20°C; 1 h;
参考文献
WO2006/76644 A2, ;
Page/Page column 204-205 ;
WO 2006/076644 A2
反应条件
hydrogen; palladium on activated charcoal in methanol P=1034.3 - 1551.4 Torr; 3 h;
参考文献
Cai, Sui Xiong; Huang, Jin-Cheng; Espitia, Stephen A.; Tran, Minhtam; Ilyin, Victor I.; Hawkinson, Jon E.; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3679 - 3686
反应条件
hydrogenchloride; potassium hydroxide; ethanol; hydroxylamine
参考文献
Boyer; Schoen
Journal of the American Chemical Society, 1956 , vol. 78, p. 423
