1-[(4-氟苯基)甲基]-N-哌啶-4-基苯并咪唑-2-胺二氢溴酸盐合成路线 （共 15 条）
反应条件
sodium carbonate in N,N-dimethyl-formamide T=70°C;
参考文献
Janssens, Frans; Torremans, Joseph; Janssen, Marcel; Stokbroekx, Raymond A.; Luyckx, Marcel; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1934 - 1943
反应条件
potassium iodide; sodium carbonate in methanol; N,N-dimethyl-formamide
参考文献
Janssen Pharmaceutica N.V.
Patent: US4219559 A1, 1980 ;
反应条件
sodium hydride; potassium iodide 1.) DMF, 70 deg C, 10 h, 2.) DMF, 70 deg C, 12 h; Yield given. Multistep reaction;
参考文献
De Parrodi, Cecilia Anaya; Quintero-Cortes, Leticia; Sandoval-Ramirez, Jesus
Synthetic Communications, 1996 , vol. 26, # 17 p. 3323 - 3329
反应条件
1: 46.7 percent / Na2CO3 / dimethylformamide / 20 h / 70 °C 2: 88.5 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
Janssens, Frans; Torremans, Joseph; Janssen, Marcel; Stokbroekx, Raymond A.; Luyckx, Marcel; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1934 - 1943
反应条件
hydrogen bromide
1 h; Heating;
参考文献
De Parrodi, Cecilia Anaya; Quintero-Cortes, Leticia; Sandoval-Ramirez, Jesus
Synthetic Communications, 1996 , vol. 26, # 17 p. 3323 - 3329
反应条件
1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C
2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating
View Scheme
参考文献
Janssens, Frans; Torremans, Joseph; Janssen, Marcel; Stokbroekx, Raymond A.; Luyckx, Marcel; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1934 - 1943
反应条件
1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C
2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating
View Scheme
参考文献
Janssens, Frans; Torremans, Joseph; Janssen, Marcel; Stokbroekx, Raymond A.; Luyckx, Marcel; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1934 - 1943
反应条件
1.1: sodium hydroxide / water / 1 h / 5 °C
1.2: 2 h / 60 - 70 °C
2.1: ethanol / 20 °C
3.1: mercury(II) oxide / ethanol / 2 h / |Reflux
4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 h / 70 - 80 °C
5.1: hydrogen bromide / 2 h / |Reflux
View Scheme
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
反应条件
1: ethanol / 20 °C
2: mercury(II) oxide / ethanol / 2 h / |Reflux
3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 h / 70 - 80 °C
4: hydrogen bromide / 2 h / |Reflux
View Scheme
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
反应条件
1: mercury(II) oxide / ethanol / 2 h / |Reflux
2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 h / 70 - 80 °C
3: hydrogen bromide / 2 h / |Reflux
View Scheme
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
