(1H-苯并咪唑-2-基)-哌啶-4-胺双氢溴酸合成路线 （共 5 条）
反应条件
hydrogen bromide
2 h; Reflux;
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
反应条件
1.1: sodium hydroxide / water / 1 h / 5 °C
1.2: 2 h / 60 - 70 °C
2.1: ethanol / 20 °C
3.1: mercury(II) oxide / ethanol / 2 h / |Reflux
4.1: hydrogen bromide / 2 h / |Reflux
View Scheme
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
反应条件
1: ethanol / 20 °C
2: mercury(II) oxide / ethanol / 2 h / |Reflux
3: hydrogen bromide / 2 h / |Reflux
View Scheme
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
反应条件
1: mercury(II) oxide / ethanol / 2 h / |Reflux
2: hydrogen bromide / 2 h / |Reflux
View Scheme
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
反应条件
sodium carbonate in N,N-dimethyl-formamide
T=70°C;
参考文献
Janssens; Torremans; Janssen; Stokbroekx; Luyckx
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1925 - 1933
