2-(1-苯并噻吩-3-基)乙酸甲酯合成路线 （共 4 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C;
参考文献
WYETH; VIROPHARMA INCORPORATED
Patent: WO2005/16932 A1, 2005 ;
Location in patent: Page/Page column 39-40 ;
反应条件
hydrogenchloride
1 h; Heating;
参考文献
Pour, Milan; Spulak, Marcel; Balsanek, Vojtech; Kunes, Jiri; Kubanova, Petra; Buchta, Vladimir
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2843 - 2866
反应条件
in methanol; hexane; benzene
T=0 - 20°C; 1 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1479681 A1, 2004 ;
Location in patent: Page 96 ;
反应条件
hydrogenchloride
1.) 10 deg C, 40 h, 2.) reflux, 8 h;
参考文献
Copp, Frederick C.; Franzmann, Karl W.; Gilmore, Jeremy; Whalley, W. Basil
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 5 p. 909 - 914
