反应条件
1.1: ethanol / 6 h / 760.05 Torr / |Reflux
2.1: hydrogen bromide; acetic acid / 2 h / 40 - 55 °C / 760.05 Torr
2.2: 760.05 Torr / |Cooling with ice
3.1: sodium hydroxide; water / 1,4-dioxane / 12 h / 760.05 Torr / |Reflux
3.2: 760.05 Torr / pH 1
View Scheme
参考文献
INFINITY PHARMACEUTICALS INC.; INTELLIKINE, LLC; CASTRO, Alfredo, C.; EVANS, Catherine, A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel, A.; TREMBLAY, Martin, R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina
Patent: WO2013/12915 A1, 2013 ;
WO 2013/012915 A1