(S)-(+)-2,2-二甲基环丙烷甲酰胺合成路线 （共 10 条）
反应条件
1: With thionyl chloride in dichloromethane T=20°C; 2: With ammonia in dichloromethane T=-15°C;
参考文献
CLS LABORATORIES, INC.
Patent: WO2004/5241 A1, 2004 ;
Location in patent: Page 10 ;
反应条件
water in acetonitrile T=30°C; pH=8.2; 2.33333 h; Enzymatic reaction; SolventConcentration; enantioselective reaction;
参考文献
Zheng, Ren-Chao; Wang, Yuan-Shan; Zheng, Yu-Guo; Shen, Yin-Chu
Catalysis Communications, 2012 , vol. 18, p. 68 - 71
反应条件
ammonia; Candida antarctica Type B lipase in tert-butyl alcohol T=30 - 40°C; 20 h; Enzymatic reaction; Product distribution / selectivity;
参考文献
CHOONGWAE PHARMA CORPORATION; CHEMICO LTD.; CHIROAD INC.
Patent: WO2007/69841 A1, 2007 ;
Location in patent: Page/Page column 9-13 ;
反应条件
ammonium hydroxide in ethanol 0.75 h;
参考文献
Graham, Donald W.; Ashton, Wallace T.; Barash, Louis; Brown, Jeannette E.; Brown, Ronald D.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1074 - 1090
反应条件
1: With toluene-4-sulfonic acid in dichloromethane T=20°C; 2: With sodium hydroxide; water in dichloromethane pH=8 - 9; Product distribution / selectivity;
参考文献
US7371897 B1, ;
Page/Page column 6 ;
参考文献
Fujisawa, Tamotsu; Ito, Takatoshi; Nishiura, Shin; Shimizu, Makoto
Tetrahedron Letters, 1998 , vol. 39, # 52 p. 9735 - 9738
反应条件
2: 93 percent / pyridine / 1.5 h / Ambient temperature 3: 83 percent / 3 M NH3 / ethanol / 0.75 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 6 p. 1074 - 1090
反应条件
1: 72 percent / Na2Cr2O7, H2SO4 / acetic acid 2: 72 percent / aminolysis View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 52 p. 9735 - 9738
反应条件
1: 28 percent / toluene / Heating 2: 1.) NH3 (liq.), Na / 2.) MeOH, 45 deg C, 15 min View Scheme
参考文献
Orchid ChemicalsandPharmaceuticals Limited
Patent: EP2402312 A1, 2012 ;
参考文献
Kim, Hyun Chang; Choi, Soojin; Kim, Hongdoo; Ahn, Kwang-Hyun; Koh, Jeong Hwan; Park, Jaiwook
Tetrahedron Letters, 1997 , vol. 38, # 22 p. 3959 - 3962
