1-(4’-硝基苯基)-2-三甲基甲硅烷基乙酰亚基合成路线 （共 17 条）
反应条件
1: aq. NaOH / diethyl ether; methanol / 18 h 2: CuSO4; sodium ascorbate; KHCO3 / 2-methyl-propan-2-ol; H2O / 24 h / 50 °C 3: aq. NaOH / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Soellner, Matthew B.; Rawls, Katherine A.; Grundner, Christoph; Alber, Tom; Ellman, Jonathan A.
Journal of the American Chemical Society, 2007 , vol. 129, # 31 p. 9613 - 9615
反应条件
potassium carbonate in methanol T=25°C; 3 h;
参考文献
Journal of Chemical Research, , # 12 p. 728 - 732
反应条件
potassium carbonate in methanol; hexane
反应条件
hydrogenchloride; aq. KOH in methanol; 2,4-dimethylbutane; ethyl acetate
反应条件
potassium carbonate 24 h; Heating;
参考文献
Tetrahedron Letters, , vol. 44, # 41 p. 7611 - 7612
反应条件
TPGS–750–M; ammonium chloride; zinc in water T=20°C; 6 h; Green chemistry; chemoselective reaction;
参考文献
Kelly, Sean M.; Lipshutz, Bruce H.
Organic Letters, 2014 , vol. 16, # 1 p. 98 - 101
反应条件
1: aq. NaOH / diethyl ether; methanol / 18 h 2: CuSO4; sodium ascorbate; KHCO3 / 2-methyl-propan-2-ol; H2O / 24 h / 50 °C View Scheme
参考文献
Soellner, Matthew B.; Rawls, Katherine A.; Grundner, Christoph; Alber, Tom; Ellman, Jonathan A.
Journal of the American Chemical Society, 2007 , vol. 129, # 31 p. 9613 - 9615
反应条件
1: With cesium fluoride in dimethyl sulfoxide T=20°C; 3 h; Schlenk technique; 2: With hydrogenchloride in water T=0°C; pH=> 1;
参考文献
Yonemoto-Kobayashi, Misato; Inamoto, Kiyofumi; Tanaka, Yoshiyuki; Kondo, Yoshinori
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 23 p. 3773 - 3775
反应条件
1: trimethylsilylacetylene With piperidine; indium tribromide
T=20°C; 2.5 h;
2: para-nitro iodo-benzene With piperidine; bis-triphenylphosphine-palladium(II) chloride
T=20°C; 1 h;
参考文献
Purdue Research Foundation; Stauffacher, Cynthia; Lipton, Mark Alfred; Saleem, Mohamed Naguieb; Schmidt, Tim Jonathan; Steussy, JR., Calvin Nicklaus; Rodwell, Victor W.
Patent: US2013/331450 A1, 2013 ;
Location in patent: Paragraph 0049 ;
反应条件
diisopropylammonium bromide; [(t-Bu)3PH]BF4; copper(l) iodide; Na2[PdCl4] in various solvent(s)
T=80°C; Sonogashira coupling; 12 h;
参考文献
Koellhofer, Axel; Plenio, Herbert
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 9 p. 1295 - 1300
