2-异丙氧基-3-甲氧基苯甲醛合成路线 （共 9 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20 - 110°C; Industry scaleInert atmosphere;
参考文献
BIONOMICS LIMITED; FLYNN, Bernard Luke
Patent: WO2012/6686 A1, 2012 ;
Location in patent: Page/Page column 20 ;
反应条件
potassium carbonate in N-methyl-acetamide; water
参考文献
Blechert, Siegfried
Patent: US2003/220512 A1, 2003 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane; water
T=20°C; 36 h;
参考文献
Philippo; Fett; Bovy; Barras; Angel; Georges; Ochsenbein
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 11 p. 881 - 888
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile
T=20°C;
参考文献
Williams, Craig M.; Mander, Lewis N.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 667 - 669
反应条件
1: m-CPBA / CH2Cl2
2: NaOH / methanol
3: 85 percent / KI; K2CO3 / acetone
4: 91 percent / BCl3 / CH2Cl2
5: 91 percent / H5IO6; CrO3 / acetonitrile; H2O
View Scheme
参考文献
Su, Chung-Ren; Shen, Yuh-Chiang; Kuo, Ping-Chung; Leu, Yann-Lii; Damu, Amooru G.; Wang, Yea-Hwey; Wu, Tian-Shung
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6155 - 6160
反应条件
1: m-CPBA / CH2Cl2
2: NaOH / methanol
3: 85 percent / KI; K2CO3 / acetone
4: 91 percent / BCl3 / CH2Cl2
5: 91 percent / H5IO6; CrO3 / acetonitrile; H2O
6: 83 percent / Na2S2O4 / H2O
View Scheme
参考文献
Su, Chung-Ren; Shen, Yuh-Chiang; Kuo, Ping-Chung; Leu, Yann-Lii; Damu, Amooru G.; Wang, Yea-Hwey; Wu, Tian-Shung
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6155 - 6160
反应条件
1: m-CPBA / CH2Cl2
2: NaOH / methanol
3: 85 percent / KI; K2CO3 / acetone
View Scheme
参考文献
Su, Chung-Ren; Shen, Yuh-Chiang; Kuo, Ping-Chung; Leu, Yann-Lii; Damu, Amooru G.; Wang, Yea-Hwey; Wu, Tian-Shung
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6155 - 6160
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Industry scale
1.2: 2 h / 20 °C / Industry scale
2.1: iodine; copper (II) acetate monohydrate; acetic acid / 22 h / 55 °C / Industry scale
3.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 °C / Inert atmosphere; Industry scale; Reflux
3.2: 39 h / 30 °C / 51.72 - 206.87 Torr / Inert atmosphere; Industry scale
3.3: 0.5 h / 30 °C / Inert atmosphere; Industry scale
4.1: boron trichloride / dichloromethane / 2.2 - 22.9 °C / Inert atmosphere; Industry scale
4.2: 0.8 h / 3.8 - 19.9 °C / Industry scale
View Scheme
参考文献
BIONOMICS LIMITED; FLYNN, Bernard Luke
Patent: WO2012/6686 A1, 2012 ;
反应条件
1.1: triphenylphosphine / CH2Cl2 / 0.25 h / 0 °C
1.2: 61 percent / CH2Cl2 / 0.83 h / 0 - 20 °C
2.1: 76 percent / n-BuLi / CH2Cl2; hexane / 3.25 h / cooling
View Scheme
参考文献
Williams, Craig M.; Mander, Lewis N.
Organic Letters, 2003 , vol. 5, # 19 p. 3499 - 3502
