3-乙氧基-2-甲氧基苯甲醛合成路线 （共 4 条）
反应条件
cerium(III) chloride; sodium iodide in acetonitrile dealkylation; 10 h; Heating;
参考文献
Chemistry Letters, , # 7 p. 738 - 739
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; 5 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1688138 A1, 2006 ;
Location in patent: Page/Page column 110-111 ;
EP 1688138 A1
反应条件
1: 2-hydroxy-3-ethoxy-benzaldehyde With caesium carbonate in N,N-dimethyl-formamide
T=20°C; 0.0833333 h;
2: ethyl iodide in N,N-dimethyl-formamide
T=40°C; Inert atmosphere;
参考文献
EXONHIT S.A.; LEBLOND, Bertrand; TAVERNE, Thierry; BEAUSOLEIL, Eric; CHAUVIGNAC, Cedric; CASAGRANDE, Anne-Sophie; DESIRE, Laurent
Patent: WO2011/151423 A1, 2011 ;
Location in patent: Page/Page column 134-135 ;
反应条件
potassium carbonate in dimethyl sulfoxide
T=40°C; 6 h;
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
