反应条件
1.1: thionyl chloride; N,N-dimethyl-formamide / 2 h / |Reflux 1.2: 2 h / 20 °C 2.1: |Reflux 3.1: trichlorophosphate; N,N-dimethyl-formamide / acetonitrile / 20 °C / |Reflux View Scheme
参考文献
INFINITY PHARMACEUTICALS INC.; INTELLIKINE, LLC; CASTRO, Alfredo, C.; EVANS, Catherine, A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel, A.; TREMBLAY, Martin, R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina
Patent: WO2013/12915 A1, 2013 ;
WO 2013/012915 A1