(5-氯-2-甲氧基苯基)乙酸合成路线 （共 10 条）
反应条件
sulfuryl dichloride in tetrahydrofuran
参考文献
Bristol-Myers Squibb Company
Patent: US5808095 A1, 1998 ;
反应条件
sulfuric acid 2 h; Heating;
参考文献
Verhe; De Kimpe; De Buyck; et al.
Bulletin des Societes Chimiques Belges, 1980 , vol. 89, # 6 p. 459 - 485
反应条件
1: With potassium hydroxide; ethanol; water 18 h; Heating / reflux; 2: With hydrogenchloride in water T=0°C; 0.25 h;
参考文献
WO2006/133802 A1, ;
Page/Page column 66 ;
WO 2006/133802 A1
反应条件
1: 93 percent / ethanol; H2O / 6 h / Heating 2: 70 percent / aq. sulfuric acid / 2 h / Heating View Scheme
参考文献
Bulletin des Societes Chimiques Belges, , vol. 89, # 6 p. 459 - 485
反应条件
1: 67 percent / zinc chloride, hydrogen chloride / 2 h / 70 °C 2: 93 percent / ethanol; H2O / 6 h / Heating 3: 70 percent / aq. sulfuric acid / 2 h / Heating View Scheme
参考文献
Bulletin des Societes Chimiques Belges, , vol. 89, # 6 p. 459 - 485
反应条件
(i) sulfur, Mor, (ii) NaOH, EtOH; Multistep reaction;
参考文献
Bulletin de la Societe Chimique de France, , p. 3311 - 3318
参考文献
US6359151 B2, ;
Page column 80 ;
反应条件
potassium carbonate in acetonitrile T=82°C; 1.58333 h; Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: EP946173 B1, 2005 ;
Location in patent: Page/Page column 10 ;
反应条件
dimethyl sulfate in glacial AcOH; water; acetonitrile
参考文献
Bristol-Myers Squibb Company
Patent: US5602169 A1, 1997 ;
US 5602169 A
反应条件
hydrogen bromide 24 h; Heating;
参考文献
Verhe; De Kimpe; De Buyck; et al.
Bulletin des Societes Chimiques Belges, 1980 , vol. 89, # 6 p. 459 - 485
