6-氯哒嗪-3-羧酸乙酯合成路线 （共 10 条）
反应条件
2-(N,N-dimethylamino)-pyridine in ethanol
参考文献
Abbott Laboratories
Patent: US5250548 A1, 1993 ;
US 5250548 A
反应条件
trichlorophosphate in chloroform
反应条件
trichlorophosphate T=100°C; 2 h;
参考文献
Morishita; Kobayashi; Yamada; Yajima
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 2 p. 371 - 372
反应条件
1: 52.5 percent / HCl / 14 h / Heating 2: 84.4 percent / POCl3 / 2 h / 100 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 2 p. 371 - 372
反应条件
1: K2Cr2O7 2: 52.5 percent / HCl / 14 h / Heating 3: 84.4 percent / POCl3 / 2 h / 100 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 2 p. 371 - 372
反应条件
1: hydrogenchloride 2: trichlorophosphate View Scheme
反应条件
diisobutylaluminium hydride in tetrahydrofuran T=0°C; 0.25 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/56817 A1, 2004 ;
Location in patent: Page 91-92 ;
WO 2004/056817 A1
反应条件
1: sodium azide / dimethyl sulfoxide / 120 °C 2: hydrogenchloride / dimethyl sulfoxide / 2 h / 120 °C View Scheme
参考文献
Kandalkar, Sachin R.; Kaduskar, Rahul D.; Ramaiah, Parimi Atchuta; Barawkar, Dinesh A.; Bhuniya, Debnath; Deshpande, Anil M.
Tetrahedron Letters, 2013 , vol. 54, # 5 p. 414 - 418
参考文献
Libermann; Rouaix
Bulletin de la Societe Chimique de France, 1959 , p. 1793,1796
反应条件
in toluene
3 h; Heating;
参考文献
Szilagyi; Kasztreiner; Matyus; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 111 - 117
