6-(甲氧基羰基)-2-萘酸合成路线 （共 23 条）
反应条件
potassium hydroxide in 1,4-dioxane; methanol
T=80°C; 2 h;
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
sodium in N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
参考文献
Karl Thomae GmbH
Patent: US5541343 A1, 1996 ;
反应条件
1: thionyl chloride, pyridine / CH2Cl2
2: pyridine / CH2Cl2
View Scheme
参考文献
Green; Simpson; Zhou; Ho; Blough
Journal of the American Chemical Society, 1990 , vol. 112, # 20 p. 7337 - 7346
反应条件
pyridine in dichloromethane
参考文献
Green; Simpson; Zhou; Ho; Blough
Journal of the American Chemical Society, 1990 , vol. 112, # 20 p. 7337 - 7346
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
6: 90 percent / NaN3 / acetone / 1.5 h / 20 °C
7: 67 percent / H2SO4 / 1 h / 0 - 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
6: 90 percent / NaN3 / acetone / 1.5 h / 20 °C
7: 67 percent / H2SO4 / 1 h / 0 - 20 °C
8: 34 percent / aq. K2CO3 / dioxane / 0.17 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: With borane in tetrahydrofuran
15 h;
2: With manganese(IV) oxide in dichloromethane
15 h;
参考文献
GALDERMA RESEARCH and DEVELOPMENT,S.N.C.
Patent: WO2004/46096 A2, 2004 ;
Location in patent: Page 59-60 ;
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: iPr2NEt; HATU / dimethylformamide / 18 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: iPr2NEt; HATU / dimethylformamide / 18 h / 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
反应条件
1: SOCl2; DMAP / toluene / 1 h / Heating
2: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
3: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
4: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
5: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
6: 96 percent / Et3N / CH2Cl2 / 2.75 h / 0 - 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
