3-(4-氯苯基)丙二醛合成路线 （共 26 条）
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 80 °C / |Cooling with ice; |Inert atmosphere 2: pyridinium chlorochromate / dichloromethane / 4 h / 0 °C View Scheme
参考文献
Organic Letters, , vol. 14, # 17 p. 4394 - 4397
反应条件
1: 86 percent / LiAlH4 / diethyl ether / 20 h 2: 62 percent / pyridinium chlorochromate / CH2Cl2 / 20 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 20 p. 4573 - 4577
反应条件
1.1: piperidine / ethanol / 5 h / Reflux; Inert atmosphere 2.1: sodium tetrahydroborate; acetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere 2.2: 2 h / 20 °C / Inert atmosphere View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 47, # 1 p. 125 - 137
反应条件
[Rh(acac)2(CO)2]; C41H50O3P2; hydrogen T=30°C; 3 h; AutoclaveInert atmosphere; Time; enantioselective reaction;
参考文献
Chemical Communications, , vol. 50, # 12 p. 1475 - 1477
反应条件
1: With ammonium hydroxide; ammonium chloride in ethanol T=20°C; 24 h; 2: With hydrogenchloride in ethanol 6 h; Heating;
参考文献
Nestl, Bettina M.; Glueck, Silvia M.; Hall, Melanie; Kroutil, Wolfgang; Stuermer, Rainer; Hauer, Bernhard; Faber, Kurt
European Journal of Organic Chemistry, 2006 , # 20 p. 4573 - 4577
反应条件
1: 43 percent / sodium acetate / methanol / 1.5 h / Heating
2: 1.) 1 M borane - THF complex, 2.) 5 M aq. NaOH / 1.) THF, reflux, 24 h, 2.) MeOH, reflux, 2 h
View Scheme
参考文献
Wrigglesworth, Roger; Walpole, Christopher S. J.; Bevan, Stuart; Campbell, Elizabeth A.; Dray, Andy; Hughes, Glyn A.; James, Iain; Masdin, Kay J.; Winter, Janet
Journal of Medicinal Chemistry, 1996 , vol. 39, # 25 p. 4942 - 4951
