1-(4-(苄氧基)-5-甲氧基-2-硝基苯基)乙酮合成路线 (共 9 条)
反应条件
1.1: zinc; ammonium chloride / ethanol; water / 5 h / Reflux 2.1: sodium methylate / ethylene glycol dimethyl ether / 1 h / 0 °C 2.2: 0 - 20 °C View Scheme
参考文献
MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; ULLRICH, Axel; TORKA, Robert; ZHANG, Yixiang; KERI, Gyoergy; OeRFI, Laszlo; SZABADKAI, Istvan
Patent: WO2011/45084 A1, 2011 ;
WO 2011/045084 A1
反应条件
1.1: zinc; ammonium chloride / ethanol; water / 5 h / Reflux 2.1: sodium methylate / ethylene glycol dimethyl ether / 1 h / 0 °C 2.2: 0 - 20 °C 3.1: trichlorophosphate / 3 h / 110 °C 3.2: Cooling with ice View Scheme
参考文献
WO2011/45084 A1, ;
WO 2011/045084 A1
反应条件
nitric acid in acetic acid
参考文献
Efficient Pharma Management Corporate
Patent: US2012/15908 A1, 2012 ;
Location in patent: Page/Page column 17 ;
反应条件
1: 98 percent / potassium carbonate; potassium iodide / acetonitrile / 24 h / Heating
2: 67 percent / HNO3 / acetic acid / 24 h / 20 °C
View Scheme
参考文献
Mizuta, Hironori; Watanabe, Soichiro; Sakurai, Yuji; Nishiyama, Keiko; Furuta, Toshiaki; Kobayashi, Yoshiro; Iwamura, Michiko
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 3 p. 675 - 683
反应条件
1: potassium carbonate / N,N-dimethyl-formamide
2: nitric acid; acetic acid
View Scheme
参考文献
Umeda, Nobuhiro; Ueno, Tasuku; Pohlmeyer, Christopher; Nagano, Tetsuo; Inoue, Takanari
Journal of the American Chemical Society, 2011 , vol. 133, # 1 p. 12 - 14
反应条件
1: potassium carbonate
2: nitric acid
View Scheme
参考文献
Azagarsamy, Malar A.; Anseth, Kristi S.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 51 p. 13803 - 13807
Angew. Chem., 2013 , vol. 125, # 51 p. 14048 - 14052,5
反应条件
ammonium formate; iron in water; toluene
T=103°C;
参考文献
XI, Dr. Ning
Patent: US2012/219522 A1, 2012 ;
Location in patent: Page/Page column 28 ;
反应条件
iron; potassium carbonate in dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether
参考文献
Zeneca Limited; Zeneca Pharma S.A.
Patent: US6514971 B1, 2003 ;
US 6514971 B1
反应条件
nitric acid; iron; potassium carbonate in dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether
参考文献
Hennequin, Laurent Francois Andre
Patent: US2003/212055 A1, 2003 ;