2-氯-4-(4-甲氧基苯基)嘧啶合成路线 （共 9 条）
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in water; acetonitrile T=90°C; 16 h;
参考文献
METHYLGENE INC.
Patent: WO2005/92899 A1, 2005 ;
Location in patent: Page/Page column 61 ;
反应条件
1: 1-bromo-4-methoxy-benzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.833333 h; 2: With zinc dibromide in tetrahydrofuran; hexane T=-78 - 20°C; 3: 2,4-Dichloro-pyrimidine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran Heating; Further stages.;
参考文献
Simkovsky, Nadja M.; Ermann, Monika; Roberts, Stanley M.; Parry, David M.; Baxter, Andy D.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 16 p. 1847 - 1849
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=50°C; 2 h;
参考文献
Sandosham, Jessie; Undheim, Kjell; Rise, Frode
Heterocycles, 1993 , vol. 35, # 1 p. 235 - 244
反应条件
potassium fluoride; [P(t-Bu)3Pd(μ-Br)]2 in tetrahydrofuran; water T=20°C; Suzuki coupling; 2 h; Inert atmosphere; regioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 134, # 1 p. 606 - 612
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate 0.25 h; 2: 1-(4-Methoxy-phenyl)-eth-(E)-ylidene-cyanamide in acetonitrile Vilsmeier-Haack reaction; 1 h; Heating;
参考文献
Cuccia, Salvatore J.; Fleming, Linda B.; France, Donald J.; Wood, William W.
Synthetic Communications, 2002 , vol. 32, # 19 p. 3011 - 3018
反应条件
1.1: titanium tetrachloride / CH2Cl2 / 1.25 h 1.2: 87 percent / CH2Cl2 2.1: phosphorus oxychloride / 0.25 h 2.2: 39 percent / acetonitrile / 1 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 32, # 19 p. 3011 - 3018
反应条件
zinc dibromide; tetrakis(triphenylphosphine) palladium(0) Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Heterocycles, , vol. 35, # 1 p. 235 - 244
反应条件
tetrakis(triphenylphosphine) palladium(0) 1.) reflux, 2 h, 2.) reflux, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Heterocycles, , vol. 35, # 1 p. 235 - 244
反应条件
in N,N-dimethyl-formamide T=50°C; 1 h;
参考文献
Sandosham, Jessie; Undheim, Kjell; Rise, Frode
Heterocycles, 1993 , vol. 35, # 1 p. 235 - 244
