1-甲醛基 -4-甲基哌嗪合成路线 （共 16 条）
反应条件
1: 1-methyl-piperazine With formic acid 0.25 h; cooling; 2: 4-formyl-benzoic acid T=180 - 200°C; Leuckart-Wallach reaction; 8 h; Further stages.;
参考文献
Ignatovich; Gusak; Chernikhova; Kozlov; Koroleva
Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 12 p. 1540 - 1543
参考文献
Yakugaku Zasshi, , vol. 74, p. 1049
Chem.Abstr., , p. 11666
参考文献
Fujii et al.
Yakugaku Zasshi, 1954 , vol. 74, p. 1049
Chem.Abstr., 1955 , p. 11666
反应条件
n-butyllithium 1.) Et2O, 15 h, room temp. 2.) 0 deg C; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 27, # 16 p. 1793 - 1796
反应条件
1: toluene / 2 h / 90 °C 2: triethylamine / toluene / 4 h / 100 °C 3: conc. HCl / H2O / 2 h / Heating View Scheme
参考文献
Gueremy; Audiau; Renault; Benavides; Uzan; Le Fur
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1394 - 1398
反应条件
in ethanol
Ambient temperature;
参考文献
Khromov-Borisov, N. V.; Aleksandrova, L. N.; Danilov, A. F.; Shelkovnikov, S. A.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 6 p. 401 - 403
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 6 p. 689 - 691
