5-氨基-1,2,4-噻二唑合成路线 （共 10 条）
反应条件
1: With hydroxylamine-o-sulphonic acid in ethanol T=80°C; 8 h; 2: With triethylamine in ethanol T=20°C; 19 h;
参考文献
US2009/124655 A1, ;
Page/Page column 14 ;
US 20090124655 A1
反应条件
1: in methanol T=20°C; 0.166667 h; 2: With bromine; sodium methylate in methanol T=-15 - 20°C; 4 h;
参考文献
US2009/124655 A1, ;
Page/Page column 14 ;
US 20090124655 A1
反应条件
bromine; sodium methylate
参考文献
Chemische Berichte, , vol. 87, p. 68,74
Chemische Berichte, , vol. 89, p. 1534,1540
参考文献
Chemische Berichte, , vol. 87, p. 68,74
Chemische Berichte, , vol. 89, p. 1534,1540
参考文献
Chemische Berichte, , vol. 87, p. 68,74
Chemische Berichte, , vol. 89, p. 1534,1540
反应条件
1: in toluene 2 h; Reflux; 2: With methanol; sodium tetrahydroborate T=20°C;
参考文献
PFIZER LIMITED; ICAGEN, INC.; GREENER, Benjamin Scott; MARRON, Brian Edward; MILLAN, David Simon; RAWSON, David James; STORER, Robert Ian; SWAIN, Nigel Alan
Patent: WO2012/4714 A2, 2012 ;
Location in patent: Page/Page column 57-58 ;
WO 2012/004714 A2
反应条件
1: 2-amino-1,3,5-thiadiazole; 2,4-di-(methoxy)-benzaldehyde With [TiCl(isopropoxy)3] in dichloromethane 0.75 h; 2: sodium tris(acetoxy)borohydride in dichloromethane T=20 - 34°C; 2 h;
参考文献
AMGEN INC.; BOEZIO, Christiane; BOEZIO, Alessandro; BREGMAN, Howard; CHAKKA, Nagasree; COATS, James R.; COPELAND, Katrina W.; DIMAURO, Erin F.; DINEEN, Thomas; GAO, Hua; LA, Daniel; MARX, Isaac E.; NGUYEN, Hanh Nho; PETERSON, Emily Anne; WEISS, Matthew
Patent: WO2013/122897 A1, 2013 ;
Location in patent: Page/Page column 63; 64 ;
反应条件
hydrogenchloride; copper; sodium nitrite
参考文献
Goerdeler et al.
Chemische Berichte, 1956 , vol. 89, p. 1534,1540
参考文献
Pentimalli,L. et al.
Gazzetta Chimica Italiana, 1977 , vol. 107, p. 1 - 5
反应条件
1: With hydrogen bromide; copper; sodium nitrite in water
T=-15 - 40°C; 2.5 h;
2: With sodium hydroxide in water
pH=6.2;
参考文献
SKW STICKSTOFFWERKE PIESTERITZ GMBH
Patent: WO2005/7636 A1, 2005 ;
Location in patent: Page/Page column 16 ;
