2-羟甲基-15-冠-5合成路线 （共 19 条）
反应条件
hydrogen in ethanol P=3102.9 Torr; 16 h; Ambient temperature;
参考文献
Johansson, Gary; Percec, Virgil; Ungar, Goran; Abramic, Darija
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 4 p. 447 - 460
反应条件
perchloric acid; palladium on activated charcoal in ethanol T=80°C; 24 h;
参考文献
Ikeda, Isao; Emura, Hiroshi; Okahara, Mitsuo
Synthesis, 1984 , # 1 p. 73 - 74
反应条件
2: 89 percent / p-TsOH, H2 / Pd-carbon / dioxane / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 26 p. 5355 - 5358
反应条件
1: 56 percent / NaOH / dioxane / 18 h / 80 °C 2: hydrogen, p-toluenesulphonic acid / Pd/C / 25 °C / 7500.6 Torr View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2500 - 2507
反应条件
1: lithium t-butoxide, lithium bromide / 2-methyl-propan-2-ol 2: hydrogen / palladium carbon View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 3 p. 447 - 450
反应条件
1: 22.8 percent 2: 100 percent / H2 / aq. ethanol / 16 h / 3102.9 Torr / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 4 p. 447 - 460
反应条件
1: 1) NaH (80percent in paraffine oil) / 1) 30 min, r. t., THF, 2) 12 h, reflux 2: 96 percent / H2, Pd/C (10percent) / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 5 p. 770 - 801
反应条件
1.1: 56 percent / NaOH / tetrahydrofuran / 20 °C 2.1: ethanol / 6 h / Heating 2.2: 56.4 percent / KOH / H2O / 3 h / Heating View Scheme
参考文献
Flink, Simon; Boukamp, Bernard A.; Van Den Berg, Albert; Van Veggel, Frank C. J. M.; Reinhoudt, David N.
Journal of the American Chemical Society, 1998 , vol. 120, # 19 p. 4652 - 4657
反应条件
1: 70 percent / diethylazodicarboxylate, triphenylphosphine / tetrahydrofuran / 10 h / Ambient temperature 2: hydrazine hydrate / methanol / 1 h / Heating View Scheme
参考文献
Bubnis, B. P.; Pacey, G. E.
Tetrahedron Letters, 1984 , vol. 25, # 11 p. 1107 - 1110
反应条件
1: 87 percent / pyridine / 1 h
2: 49 percent
View Scheme
参考文献
Nakatsuji, Yohji; Nakamura, Tetsuya; Okahara, Mitsuo; Dishong, Dennis M.; Gokel, George W.
Journal of Organic Chemistry, 1983 , vol. 48, # 8 p. 1237 - 1242
