1,3-二苄基-5-氟尿嘧啶合成路线 (共 5 条)
反应条件
boron tribromide in various solvent(s) T=138°C; 24 h;
参考文献
Kundu, Nitya G.; Hertzberg, Robert P.; Hannon, Stephen J.
Tetrahedron Letters, 1980 , vol. 21, p. 1109 - 1112
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
LaFrate, Andrew L.; Katzenellenbogen, John A.
Journal of Organic Chemistry, 2007 , vol. 72, # 22 p. 8573 - 8576
反应条件
tetra(n-butyl)ammonium hydroxide in dichloromethane
Ambient temperature;
参考文献
Hoshiko, Tomonori; Watanabe, Yutaka; Ozaki, Shoihiro
Heterocycles, 1983 , vol. 20, # 12 p. 2429 - 2431
反应条件
potassium carbonate
1.) dimethylformamide, 2.) room temperature, 6 d; Yield given. Multistep reaction;
参考文献
Kundu; Schmitz
Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 8 p. 935 - 938
反应条件
sodium hydride
1) DMF, 0.5 h; 2) DMF, 80 deg C, 4 h; further bases (K2CO3, K-t-butoxide); other conditions; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Sanyal, Utpal; Chakraborti, S. K.
Synthetic Communications, 1982 , vol. 12, # 13 p. 1047 - 1054