2-苯基-2-哌啶乙酸乙酯合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 1.5 h;
参考文献
Chiesi Farmaceutici S.p.A.; AMARI, Gabriele; Pesenti, Cristina; Bossolo, Stefano
Patent: US2013/172302 A1, 2013 ;
Location in patent: Paragraph 0108; 0109; 0110 ;
反应条件
[Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2 in acetonitrile 7 h; Reflux;
参考文献
Deng, Qing-Hai; Xu, Hai-Wei; Yuen, Angella Wing-Hoi; Xu, Zhen-Jiang; Che, Chi-Ming
Organic Letters, 2008 , vol. 10, # 8 p. 1529 - 1532
反应条件
1: bromobenzene With cobalt(II) dibromide; zinc in acetonitrile T=20°C; 0.5 h; Inert atmosphere; 2: piperidine; glyoxylic acid ethyl ester in toluene; acetonitrile T=25°C; 1 h; Inert atmosphere;
参考文献
Haurena, Caroline; Le Gall, Erwan; Sengmany, Stephane; Martens, Thierry; Troupel, Michel
Journal of Organic Chemistry, 2010 , vol. 75, # 8 p. 2645 - 2650
反应条件
[2,2']bipyridinyl; copper(I) bromide in N,N-dimethyl-formamide T=70°C; 24 h; Inert atmosphereMolecular sieve;
参考文献
Frauenlob, Robin; Garcia, Carlos; Bradshaw, Gary A.; Burke, Helen M.; Bergin, Enda
Journal of Organic Chemistry, 2012 , vol. 77, # 9 p. 4445 - 4449
反应条件
1: benzene / 4 h / 25 °C 2: 1.) ZnCl2*Et2O / THF, 1.) 25 deg C, 45 min, 2.) room temp., 30 min View Scheme
参考文献
Synthesis, , # 4 p. 323 - 327
反应条件
ZnCl2*Et2O THF, 1.) 25 deg C, 45 min, 2.) room temp., 30 min; Yield given. Multistep reaction;
参考文献
Synthesis, , # 4 p. 323 - 327
