6-溴-2,3-二氢-1H-茚-1-醇合成路线 （共 20 条）
反应条件
1: 74 percent / NaOEt / Heating
2: 95 percent / KOH / acetic acid; H2O; tetrahydrofuran
3: 85 percent / 165 °C
4: thionyl chloride
5: 91 percent / AlCl3 / CS2
6: 89 percent / NaBH4 / ethanol / 25 °C
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 28 percent / Pseudomonas putida UV4 / 7 h
2: 88 percent / sodium borohydride / methanol / 2 h / 20 °C
View Scheme
参考文献
Boyd, Derek R.; Sharma, Narain D.; Bowers, Nigel I.; Boyle, Rosemary; Harrison, John S.; Lee, Kyoung; Bugg, Timothy D.H.; Gibson, David T.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 8 p. 1298 - 1307
反应条件
1: 90 percent / sodium borohydride / methanol / 2 h / 20 °C
2: 92 percent / p-TsOH / benzene / 2 h / Heating
3: 28 percent / Pseudomonas putida UV4 / 7 h
4: 88 percent / sodium borohydride / methanol / 2 h / 20 °C
View Scheme
参考文献
Boyd, Derek R.; Sharma, Narain D.; Bowers, Nigel I.; Boyle, Rosemary; Harrison, John S.; Lee, Kyoung; Bugg, Timothy D.H.; Gibson, David T.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 8 p. 1298 - 1307
反应条件
1: 92 percent / p-TsOH / benzene / 2 h / Heating
2: 28 percent / Pseudomonas putida UV4 / 7 h
3: 88 percent / sodium borohydride / methanol / 2 h / 20 °C
View Scheme
参考文献
Boyd, Derek R.; Sharma, Narain D.; Bowers, Nigel I.; Boyle, Rosemary; Harrison, John S.; Lee, Kyoung; Bugg, Timothy D.H.; Gibson, David T.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 8 p. 1298 - 1307
反应条件
thionyl chloride in toluene
参考文献
Dhar, T. G. Murali; Watterson, Scott H.; Chen, Ping; Shen, Zhongqi; Gu, Henry H.; Norris, Derek; Carlsen, Marianne; Haslow, Kristin D.; Pitts, William J.; Guo, Junqing; Chorba, John; Fleener, Catherine A.; Rouleau, Katherine A.; Townsend, Robert; Hollenbaugh, Diane; Iwanowicz, Edwin J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 547 - 551
反应条件
1: 97 percent / p-toluenesulfonic acid * H2O / benzene / Heating
2: 93 percent / NiCl2<dppp>2 / diethyl ether / Heating
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 97 percent / p-toluenesulfonic acid * H2O / benzene / Heating
2: 96 percent / NiCl2<dppp>2 / diethyl ether / Heating
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 97 percent / p-toluenesulfonic acid * H2O / benzene / Heating
2: 93 percent / NiCl2<dppp>2 / diethyl ether / Heating
3: H2 / PtO2 / tetrahydrofuran / 1034.3 Torr
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 97 percent / p-toluenesulfonic acid * H2O / benzene / Heating
2: 98 percent / NiCl2<dppp>2 / diethyl ether / Heating
3: H2 / PtO2 / tetrahydrofuran / 1034.3 Torr
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
反应条件
1: 97 percent / p-toluenesulfonic acid * H2O / benzene / Heating
2: 96 percent / NiCl2<dppp>2 / diethyl ether / Heating
3: H2 / PtO2 / tetrahydrofuran / 1034.3 Torr
View Scheme
参考文献
Adamczyk, Maciej; Watt, David S.; Netzel, Daniel A.
Journal of Organic Chemistry, 1984 , vol. 49, # 22 p. 4226 - 4237
