(2S,3S)-5-[2-(二甲基氨基)乙基]-3-羟基-2-(4-甲氧基苯基)-2,3-二氢-1,5-苯并硫氮杂卓-4-酮盐酸盐合成路线 （共 8 条）
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane 2: With hydrogenchloride in methanol pH=2;
参考文献
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
Patent: US2004/127704 A1, 2004 ;
Location in patent: Page 4 ;
反应条件
methanesulfonic acid in chloroform 0.75 h; Heating;
参考文献
Gizur, Tibor; Harsanyi, Kalman
Synthetic Communications, 1990 , vol. 20, # 15 p. 2365 - 2371
反应条件
water; potassium carbonate in ethyl acetate
12 h; Heating / reflux;
参考文献
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
Patent: US2004/127704 A1, 2004 ;
Location in patent: Page 3 ;
反应条件
1: 70 percent / urea hydrogen peroxide, DBU, immobilised poly-L-leucine / tetrahydrofuran / 28 h
2: 84 percent / MCPBA, KF / CH2Cl2 / 24 h
3: 90 percent / toluene / 17 h / Heating
4: 94 percent / xylene / 216 h / Heating
5: K2CO3 / ethyl acetate
View Scheme
参考文献
Adger, Brian M.; Barkley, James V.; Bergeron, Sophie; Cappi, Michael W.; Flowerdew, Benjamin E.; Jackson, Mark P.; McCague, Ray; Nugent, Thomas C.; Roberts, Stanley M.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 23 p. 3501 - 3507
反应条件
1: 87 percent / NaOMe / methanol / 40 h / Heating
2: 70 percent / urea hydrogen peroxide, DBU, immobilised poly-L-leucine / tetrahydrofuran / 28 h
3: 84 percent / MCPBA, KF / CH2Cl2 / 24 h
4: 90 percent / toluene / 17 h / Heating
5: 94 percent / xylene / 216 h / Heating
6: K2CO3 / ethyl acetate
View Scheme
参考文献
Adger, Brian M.; Barkley, James V.; Bergeron, Sophie; Cappi, Michael W.; Flowerdew, Benjamin E.; Jackson, Mark P.; McCague, Ray; Nugent, Thomas C.; Roberts, Stanley M.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 23 p. 3501 - 3507
反应条件
1: 90 percent / toluene / 17 h / Heating
2: 94 percent / xylene / 216 h / Heating
3: K2CO3 / ethyl acetate
View Scheme
参考文献
Adger, Brian M.; Barkley, James V.; Bergeron, Sophie; Cappi, Michael W.; Flowerdew, Benjamin E.; Jackson, Mark P.; McCague, Ray; Nugent, Thomas C.; Roberts, Stanley M.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 23 p. 3501 - 3507
反应条件
1: 94 percent / xylene / 216 h / Heating
2: K2CO3 / ethyl acetate
View Scheme
参考文献
Adger, Brian M.; Barkley, James V.; Bergeron, Sophie; Cappi, Michael W.; Flowerdew, Benjamin E.; Jackson, Mark P.; McCague, Ray; Nugent, Thomas C.; Roberts, Stanley M.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 23 p. 3501 - 3507
反应条件
1: 84 percent / MCPBA, KF / CH2Cl2 / 24 h
2: 90 percent / toluene / 17 h / Heating
3: 94 percent / xylene / 216 h / Heating
4: K2CO3 / ethyl acetate
View Scheme
参考文献
Adger, Brian M.; Barkley, James V.; Bergeron, Sophie; Cappi, Michael W.; Flowerdew, Benjamin E.; Jackson, Mark P.; McCague, Ray; Nugent, Thomas C.; Roberts, Stanley M.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 23 p. 3501 - 3507
