1: 96 percent / methanolic NaOH 2: 82 percent / polyphosphoric acid / 0.58 h / 70 °C 3: 1.) Raney Ni, 2.) H2 / 2.) Pd/C / 1.) ethyl acetate, reflux, 15 min, 2.) acetic acid, 70 deg C, 4 h, 50 psi 4: 55 percent / BBr3 / CH2Cl2 / 12 h View Scheme