N-[(3R)-四氢-2,5-二氧代-3-呋喃基]氨基甲酸苄酯合成路线 （共 5 条）
反应条件
1.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 25 °C 1.2: 0 °C / pH 4 2.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark conditions; Reflux 3.1: tetrahydrofuran / 14 h / 18 - 25 °C 4.1: tributylphosphine / toluene / 8 h / 80 °C View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran T=0 - 20°C; 4 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=2;
参考文献
WO2009/36051 A1, ;
Page/Page column 48 ;
WO 2009/036051 A1
反应条件
1.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 25 °C
1.2: 0 °C / pH 4
2.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark conditions; Reflux
3.1: tetrahydrofuran / 14 h / 18 - 25 °C
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
1.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 25 °C
1.2: 0 °C / pH 4
2.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark conditions; Reflux
3.1: tetrahydrofuran / 18 - 25 °C
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
反应条件
1.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 25 °C
1.2: 0 °C / pH 4
2.1: toluene-4-sulfonic acid / toluene / 3 h / Dean-Stark conditions; Reflux
3.1: tetrahydrofuran / 18 - 25 °C
4.1: tributylphosphine / toluene / 80 °C / Inert atmosphere
View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/35134 A1, 2012 ;
