4,6-二氯-2-甲基-5-(1-乙酰基-2-咪唑)-氨基吡啶合成路线 （共 16 条）
反应条件
in dimethyl sulfoxide T=25°C; 30 h; Product distribution / selectivity;
参考文献
CHEMAGIS LTD.
Patent: EP1873151 A1, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
in methanol T=0°C; 48 h; Product distribution / selectivity;
参考文献
CHEMAGIS LTD.
Patent: EP1873151 A1, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
1: With potassium carbonate in methanol T=47 - 52°C; 5 h; 2: With water; acetic acid in methanol 0.5 h; 3: With ammonia in methanol; water 1 h; Product distribution / selectivity;
参考文献
CHEMAGIS LTD.
Patent: EP1894927 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
T=30 - 35°C; 0.75 h;
参考文献
Hetero Research Foundation; Parthasaradhi Reddy, Bandi; Rathnakar Reddy, Kura; Muralidhara Reddy, Dasari; Ramakrishna Reddy, Matta; Vamsi Krishna, Bandi
Patent: EP2586779 A1, 2013 ;
Location in patent: Paragraph 0037 ;
参考文献
WO2008/73125 A1, ;
Page/Page column 14-15 ;
反应条件
2 h; Heating / reflux;
参考文献
WO2008/73125 A1, ;
Page/Page column 12 ;
