4,6-二氯-2-甲基-5-(1-乙酰基-2-咪唑)-氨基吡啶合成路线 （共 16 条）
反应条件
trichlorophosphate T=50°C; 48 h;
参考文献
EP2586779 A1, ;
Paragraph 0036 ;
反应条件
trichlorophosphate T=90°C; 7 h;
参考文献
WO2008/73125 A1, ;
Page/Page column 12-13 ;
反应条件
carbon in dimethyl sulfoxide T=90°C; 0.5 h; Purification / work up;
参考文献
WO2008/73125 A1, ;
Page/Page column 12-13 ;
反应条件
potassium hydroxide in methanol; water T=20°C; 31 h;
参考文献
CHEMAGIS LTD.
Patent: EP1894926 A1, 2008 ;
Location in patent: Page/Page column 7 ;
反应条件
sodium hydrogencarbonate in water T=65°C; 6 h; Product distribution / selectivity;
参考文献
CHEMAGIS LTD.
Patent: EP1873151 A1, 2008 ;
Location in patent: Page/Page column 9-10 ;
反应条件
sodium hydroxide in water T=25°C; 24 h; Product distribution / selectivity;
参考文献
CHEMAGIS LTD.
Patent: EP1873151 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
in methanol T=0 - 65°C; 1.5 - 48 h; Product distribution / selectivity;
参考文献
CHEMAGIS LTD.
Patent: EP1873151 A1, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
potassium carbonate T=65°C; 3 h; Product distribution / selectivity;
参考文献
CHEMAGIS LTD.
Patent: EP1873151 A1, 2008 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium hydroxide T=20°C; 30 h; Product distribution / selectivity;
参考文献
CHEMAGIS LTD.
Patent: EP1873152 A1, 2008 ;
Location in patent: Page/Page column 7 ;
