5-(3-氯苯基)-5-氧代戊酸合成路线 （共 5 条）
反应条件
1: 1-fluoro-3-chlorobenzene With iodine; magnesium in tetrahydrofuran
Reflux;
2: With copper(l) iodide in tetrahydrofuran
T=0 - 20°C; 1 h;
3: glutaric acid anhydride in tetrahydrofuran
T=0 - 20°C; 1.5 h;
参考文献
Dobish, Mark C.; Johnston, Jeffrey N.
Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6068 - 6071
反应条件
1: Mg / ethanol; CCl4; diethyl ether / 2 h / 60 °C
2: 1.) KOH, 2.) NH4Cl, 30 percent NH3 / 1.) EtOH, RT, 15 min, 2.) H2O, 2.5 h
3: 1.) NaOEt / 1.) EtOH, reflux, 30 min, 2.) EtOH, reflux, 7 h
4: 47percent HBr / Heating
View Scheme
参考文献
Cignarella, G.; Barlocco, D.; Pocar, D.; Clerici, F.; Curzu, M. M.; et al.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 9 p. 721 - 726
反应条件
hydrogen bromide
Heating; Yield given;
参考文献
Cignarella, G.; Barlocco, D.; Pocar, D.; Clerici, F.; Curzu, M. M.; et al.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 9 p. 721 - 726
反应条件
1: 1.) KOH, 2.) NH4Cl, 30 percent NH3 / 1.) EtOH, RT, 15 min, 2.) H2O, 2.5 h
2: 1.) NaOEt / 1.) EtOH, reflux, 30 min, 2.) EtOH, reflux, 7 h
3: 47percent HBr / Heating
View Scheme
参考文献
Cignarella, G.; Barlocco, D.; Pocar, D.; Clerici, F.; Curzu, M. M.; et al.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 9 p. 721 - 726
反应条件
1: 1.) NaOEt / 1.) EtOH, reflux, 30 min, 2.) EtOH, reflux, 7 h
2: 47percent HBr / Heating
View Scheme
参考文献
Cignarella, G.; Barlocco, D.; Pocar, D.; Clerici, F.; Curzu, M. M.; et al.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 9 p. 721 - 726
