N-[1-氧代-6-(苯氧基)-2,3-二氢茚-5-基]甲烷磺酰胺合成路线 （共 7 条）
反应条件
acetic anhydride in water; acetic acid
参考文献
Schering, Aktiengesellschaft
Patent: US4244960 A1, 1981 ;
反应条件
1: 75 percent / 2 h / 155 - 160 °C
2: 59 percent / O3 / CHCl3 / 0.5 h / -40 °C
3: 89 percent / N2H4*H2O / Raney-nickel / dioxane; ethanol / 1.) 50 deg C, 1 h; 2.) reflux, 30 min
4: 82 percent / pyridine / 1.) 0 deg C, 1 h; 2.) 20 deg C, 2 h
View Scheme
参考文献
Rufer; Bahlmann; Schroeder; Boettcher
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 2 p. 173 - 180
反应条件
1: 59 percent / O3 / CHCl3 / 0.5 h / -40 °C
2: 89 percent / N2H4*H2O / Raney-nickel / dioxane; ethanol / 1.) 50 deg C, 1 h; 2.) reflux, 30 min
3: 82 percent / pyridine / 1.) 0 deg C, 1 h; 2.) 20 deg C, 2 h
View Scheme
参考文献
Rufer; Bahlmann; Schroeder; Boettcher
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 2 p. 173 - 180
反应条件
1: 89 percent / N2H4*H2O / Raney-nickel / dioxane; ethanol / 1.) 50 deg C, 1 h; 2.) reflux, 30 min
2: 82 percent / pyridine / 1.) 0 deg C, 1 h; 2.) 20 deg C, 2 h
View Scheme
参考文献
Rufer; Bahlmann; Schroeder; Boettcher
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 2 p. 173 - 180
反应条件
in pyridine
1.) 0 deg C, 1 h; 2.) 20 deg C, 2 h;
参考文献
Rufer; Bahlmann; Schroeder; Boettcher
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 2 p. 173 - 180
反应条件
1: 97 percent / 10 N HCl / ethanol / 2 h / Heating
2: 82 percent / pyridine / 1.) 0 deg C, 1 h; 2.) 20 deg C, 2 h
View Scheme
参考文献
Rufer; Bahlmann; Schroeder; Boettcher
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 2 p. 173 - 180
反应条件
1: 2.) Cr2O3 / 1.) AcOH, 25 deg C, 30 min; 2.) AcOH, water, 40 deg C, 2 h
2: 97 percent / 10 N HCl / ethanol / 2 h / Heating
3: 82 percent / pyridine / 1.) 0 deg C, 1 h; 2.) 20 deg C, 2 h
View Scheme
参考文献
Rufer; Bahlmann; Schroeder; Boettcher
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 2 p. 173 - 180
