Boc-L-天冬氨酸 4-苄酯合成路线 (共 36 条)
反应条件
trifluoroacetic acid in dichloromethane 2 h; Ambient temperature;
参考文献
Liotta; Gibbs; Taylor; Benkovic
Journal of the American Chemical Society, 1995 , vol. 117, # 17 p. 4729 - 4741
参考文献
Qian; Shenderovich; Kover; Davis; Horvath; Zalewska; Yamamura; Porreca; Hruby
Journal of the American Chemical Society, 1996 , vol. 118, # 31 p. 7280 - 7290
参考文献
Schiller, Peter W.; Weltrowska, Grazyna; Nguyen, Thi M.-D.; Wilkes, Brian C.; Chung, Nga N.; Lemieux, Carole
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3956 - 3961
反应条件
1: (S)-2-[(tert-butoxy)carbonylamino]-3-(benzyloxycarbonyl)propanoic acid With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide in tetrahydrofuran
Inert atmosphereCooling;
2: L-phenylalanine With 4-methyl-morpholine in tetrahydrofuran
Inert atmosphereCooling;
参考文献
Zhao, Ming; Liu, Jiangyuan; Zhang, Xiaoyi; Peng, Li; Li, Chunyu; Peng, Shiqi
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3680 - 3689
反应条件
1: Et3N / tetrahydrofuran / 0.17 h / -15 °C
2: Et3N / tetrahydrofuran; dimethylformamide / 0 - 20 °C
3: 92 percent / zinc, acetic acid / 2 h / Ambient temperature
View Scheme
参考文献
Matsumoto; Shimohigashi; Takano; Sakaguchi; Kamiya; Ohno
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 1 p. 196 - 204
反应条件
dimercaptoethane; benzotriazol-1-ol; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid
solid phase synthesis on p-methylbenzhydrylamine resine coupled with terminal carboxy group; 1) CH2Cl2; 2) DMF; Multistep reaction;
参考文献
Hlavacek, Jan; Pirkova, jana; Zertova, Miroslava; Pospisek, Jan; Maletinska, Lenka; Slaninova, Jirina
Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 11 p. 2761 - 2765