Boc-L-天冬氨酸 4-苄酯合成路线 （共 36 条）
反应条件
dicyclohexyl-carbodiimide
参考文献
Masar, Bohumil; Schmidt, Pavel; Pivcova, Hana; Cefelin, Pavel
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 8 p. 1922 - 1927
反应条件
1: 98 percent / K2CO3 / dimethylformamide / 30 h / 0 °C 2: 96 percent / DMAP / acetonitrile / 24 h 3: 89 percent / H2 / Pd/C / methanol / 2 h / 2585.74 Torr 4: Et3N / tetrahydrofuran / 0.5 h / -10 °C 5: tetrahydrofuran; H2O / 1.5 h / -10 °C 6: 2.52 g / toluene / 2 h / Heating 7: 95 percent / CuCl / dimethylformamide / 1 h 8: 10 percent / NaOH / methanol; H2O / 2 h View Scheme
参考文献
Englund, Ethan A.; Gopi, Hosahudya N.; Appella, Daniel H.
Organic Letters, 2004 , vol. 6, # 2 p. 213 - 215
反应条件
piperidine 72 h; Ambient temperature;
参考文献
Schoen, Istvan; Szirtes, Tamas; Rill, Attila; Balogh, Gabor; Vadasz, Zsolt; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 12 p. 3213 - 3223
参考文献
Journal of Organic Chemistry, , vol. 58, # 9 p. 2369 - 2376
反应条件
pyridine; 2,4,6-tri-fluoro-1,3,5-triazine in dichloromethane; acetonitrile T=-30 - -20°C; 1 h;
参考文献
Carpino, Louis A.; Mansour, El-Sayed M. E.
Journal of Organic Chemistry, 1992 , vol. 57, # 23 p. 6371 - 6373
反应条件
1.1: Et3N / tetrahydrofuran 1.2: NaBH4 / H2O 2.1: TFA / toluene View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 19 p. 3489 - 3492
反应条件
dicyclohexyl-carbodiimide in 1,4-dioxane
参考文献
Harris, Thomas D.; Rajopadhye, Milind; Damphousse, Paul R.; Glowacka, Danuta; Yu, Karmine; Bourque, Jeffrey P.; Barrett, John A.; Damphousse, David J.; Heminway, Stuart J.; Lazewatsky, Joel; Mazaika, Theresa; Carroll, Timothy R.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 15 p. 1741 - 1746
反应条件
1: dicyclohexylcarbodiimide / tetrahydrofuran / Ambient temperature 2: 1.) trifluoroacetic acid, 2.) pyridine / 1.) RT, 30 min, 2.) RT, overnight 3: 80 percent / H2 / Pd/C / methanol View Scheme
参考文献
Bergeron, Raymond J.; Phanstiel IV, Otto; Yao, Guo Wei; Milstein, Sam; Weimar, William R.
Journal of the American Chemical Society, 1994 , vol. 116, # 19 p. 8479 - 8484
反应条件
magnesium; hydrazinium monoformate in methanol T=25°C; 1 h;
参考文献
Channe Gowda
Tetrahedron Letters, 2002 , vol. 43, # 2 p. 311 - 313
反应条件
1: N-methylmorpholine (NMM) / tetrahydrofuran / 0.1 h 2: N-methylmorpholine (NMM) / dimethylformamide / Ambient temperature 3: 1.5 N aq. HCl / acetic acid / 0.75 h / Ambient temperature 4: N-methylmorpholine (NMM) / dimethylformamide / Ambient temperature 5: 1.56 g / 1.4 N aq. HCl / acetic acid / 0.67 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 16 p. 2919 - 2928
