BOC-L-苯胺-4-硝基苯酯合成路线 （共 21 条）
反应条件
sodium hydroxide; sodium hydrogencarbonate in N,N-dimethyl-formamide 48 h;
参考文献
Bobrova, I. V.; Myshlyakova, N. A.; Papsuevich, O. S.; Vosekalna, I. A.; Mekshun, E. I.
Russian Journal of Bioorganic Chemistry, 1995 , vol. 21, # 4 p. 236 - 241
Bioorganicheskaya Khimiya, 1995 , vol. 21, # 4 p. 275 - 281
反应条件
1.1: t-BuOK / tetrahydrofuran / 2 h / Heating 1.2: tetrahydrofuran / 4 h / 0 °C 2.1: 81 percent / LiCl; MeSO3H / tetrahydrofuran / 2 h / 70 °C 3.1: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C 4.1: 96 percent / t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 16 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 5 p. 1629 - 1633
反应条件
trans-N,N'-bis-[pyridin-2-ylmethylene]-cyclohexane-1,2-diamine; sodium methylate; ytterbium(III) triflate in acetonitrile T=25°C; pH=6.5; Kinetics; Reagent/catalystpH-value; optical yield given as percent ee;
参考文献
Maxwell, Christopher I.; Shah, Kalpa; Samuleev, Pavel V.; Neverov, Alexei A.; Brown, R. Stan
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 15 p. 2796 - 2803
反应条件
trans-N,N'-bis-[pyridin-2-ylmethylene]-cyclohexane-1,2-diamine; sodium methylate; ytterbium(III) triflate in acetonitrile T=25°C; pH=6.5; Kinetics; Reagent/catalystpH-value; optical yield given as percent ee;
参考文献
Maxwell, Christopher I.; Shah, Kalpa; Samuleev, Pavel V.; Neverov, Alexei A.; Brown, R. Stan
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 15 p. 2796 - 2803
反应条件
1.1: t-BuOK / tetrahydrofuran / 2 h / Heating 1.2: tetrahydrofuran / 4 h / 0 °C 2.1: 81 percent / LiCl; MeSO3H / tetrahydrofuran / 2 h / 70 °C 3.1: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C 4.1: 96 percent / t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 16 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 5 p. 1629 - 1633
反应条件
1.1: t-BuOK / tetrahydrofuran / 2 h / Heating 1.2: tetrahydrofuran / 4 h / 0 °C 2.1: 81 percent / LiCl; MeSO3H / tetrahydrofuran / 2 h / 70 °C 3.1: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme
参考文献
Wang, Dengjin; Schwinden, Mark D.; Radesca, Lilian; Patel, Bharat; Kronenthal, David; Huang, Ming-Hsing; Nugent, William A.
Journal of Organic Chemistry, 2004 , vol. 69, # 5 p. 1629 - 1633
反应条件
potassium phosphate; template imprinted polymer in acetonitrile other reagent; also without polymer; Rate constant;
参考文献
Tomisaka; Ishida; Konishi; Aida
Chemical Communications, 2001 , # 1 p. 133 - 134
反应条件
1: dimethylformamide / 20 °C 2: 255 mg / aq. TFA / 20 °C View Scheme
参考文献
Rubina; Bespalova; Bushuev
Russian Journal of Bioorganic Chemistry, 2000 , vol. 26, # 4 p. 235 - 244
反应条件
1: 85 percent / aq. 1N NaOH / dioxane / 24 h / Ambient temperature
2: 2N HCl / acetic acid / 0.33 h
3: 1.) 4-hydroxy-3-nitrobenzophenone fixed to a polystyrene matrix, 2.) triethylamine / 2.) DMF, 20 min
4: 2N HCl / acetic acid
5: 1.) 4-hydroxy-3-nitrobenzophenone fixed to a polystyrene matrix, 2.) triethylamine / 2.) DMF, 30 min
View Scheme
参考文献
Grigor'ev, E. I.; Chernova, S. V.
Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 468 - 474
反应条件
sodium hydroxide in 1,4-dioxane
24 h; Ambient temperature;
参考文献
Grigor'ev, E. I.; Chernova, S. V.
Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 468 - 474
