3,5-二甲基-4-溴苯腈合成路线 （共 7 条）
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl acetamide; acetonitrile T=50 - 88°C;
参考文献
WO2010/62590 A2, ;
Page/Page column 30-31 ;
反应条件
carbon disulfide; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in toluene T=20°C; 20 h;
参考文献
Beinhoff, Matthias; Weigel, Wilfried; Jurczok, Martin; Rettig, Wolfgang; Modrakowski, Claudia; Bruedgam, Irene; Hartl, Hans; Schlueter, A. Dieter
European Journal of Organic Chemistry, 2001 , # 20 p. 3819 - 3829
反应条件
pyridine; hydroxylamine hydrochloride in toluene 2 h; Heating;
参考文献
European Journal of Organic Chemistry, , # 20 p. 3819 - 3829
反应条件
phosphorus pentachloride
参考文献
Journal of the American Chemical Society, , vol. 62, p. 2995,3001
反应条件
1: thionyl chloride / Behandeln des erhaltenen Saeurechlorids mit wss. Ammoniak 2: phosphorus (V)-chloride View Scheme
参考文献
Journal of the American Chemical Society, , vol. 62, p. 2995,3001
反应条件
1.1: nBuLi / diethyl ether; hexane / 0.75 h / -78 °C 1.2: 79 percent / diethyl ether; hexane / -78 - 20 °C 2.1: 39 percent / hydroxylamine hydrochloride; pyridine / toluene / 2 h / Heating View Scheme
参考文献
European Journal of Organic Chemistry, , # 20 p. 3819 - 3829
反应条件
1: 56 percent / hydroxylamine hydrochloride; pyridine / toluene / 2 h / Heating 2: 75 percent / CS2; aq. NaOH; (nBu)4NHSO4 / toluene / 20 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 20 p. 3819 - 3829
