1-乙基-6,7,8-三氟-1,4-二氢-4-氧代喹啉-2-羧酸合成路线 （共 9 条）
反应条件
hydrogenchloride; water in acetic acid 2 h; Reflux;
参考文献
Sunduru, Naresh; Gupta, Leena; Chauhan, Kuldeep; Mishra, Nripendra N.; Shukla, Praveen K.; Chauhan, Prem M.S.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1232 - 1244
反应条件
1: 1.) K2CO3 / 1.) DMF 2: HCl / acetic acid / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 5 p. 991 - 1001
反应条件
1: 2 h / 110 - 120 °C 2: diphenylether / 8 h / 250 °C 3: potassium carbonate / N,N-dimethyl-formamide / 10 h / 95 °C 4: hydrogenchloride; water / acetic acid / 2 h / Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1232 - 1244
反应条件
1: diphenylether / 8 h / 250 °C 2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 95 °C 3: hydrogenchloride; water / acetic acid / 2 h / Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1232 - 1244
反应条件
in acetonitrile Heating;
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
in acetonitrile 4 h; Heating;
参考文献
Nishimura; Minamida; Matsumoto
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 2 p. 479 - 485
反应条件
in acetonitrile
T=90°C; 7 h;
参考文献
Sunduru, Naresh; Gupta, Leena; Chauhan, Kuldeep; Mishra, Nripendra N.; Shukla, Praveen K.; Chauhan, Prem M.S.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1232 - 1244
反应条件
in dimethyl sulfoxide
T=110°C; 1 h;
参考文献
Uno, Toshio; Takamatsu, Masanori; Inoue, Yoshimasa; Kawahata, Yoshihiro; Iuchi, Koji; Tsukamoto, Goro
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2163 - 2169
反应条件
in N,N-dimethyl-formamide
T=100°C; 1.25 h;
参考文献
Uno, Toshio; Takamatsu, Masanori; Inoue, Yoshimasa; Kawahata, Yoshihiro; Iuchi, Koji; Tsukamoto, Goro
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2163 - 2169
