1-乙基-6,8-二氟-7-(4-甲基哌嗪-1-基)-4-氧代喹啉-3-羧酸合成路线 （共 5 条）
反应条件
in acetonitrile
T=90°C; 7 h;
参考文献
Sunduru, Naresh; Gupta, Leena; Chauhan, Kuldeep; Mishra, Nripendra N.; Shukla, Praveen K.; Chauhan, Prem M.S.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1232 - 1244
反应条件
1: 2 h / 110 - 120 °C
2: diphenylether / 8 h / 250 °C
3: potassium carbonate / N,N-dimethyl-formamide / 10 h / 95 °C
4: hydrogenchloride; water / acetic acid / 2 h / Reflux
5: acetonitrile / 7 h / 90 °C
View Scheme
参考文献
Sunduru, Naresh; Gupta, Leena; Chauhan, Kuldeep; Mishra, Nripendra N.; Shukla, Praveen K.; Chauhan, Prem M.S.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1232 - 1244
反应条件
1: hydrogenchloride; water / acetic acid / 2 h / Reflux
2: acetonitrile / 7 h / 90 °C
View Scheme
参考文献
Sunduru, Naresh; Gupta, Leena; Chauhan, Kuldeep; Mishra, Nripendra N.; Shukla, Praveen K.; Chauhan, Prem M.S.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1232 - 1244
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 95 °C
2: hydrogenchloride; water / acetic acid / 2 h / Reflux
3: acetonitrile / 7 h / 90 °C
View Scheme
参考文献
Sunduru, Naresh; Gupta, Leena; Chauhan, Kuldeep; Mishra, Nripendra N.; Shukla, Praveen K.; Chauhan, Prem M.S.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1232 - 1244
反应条件
1: diphenylether / 8 h / 250 °C
2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 95 °C
3: hydrogenchloride; water / acetic acid / 2 h / Reflux
4: acetonitrile / 7 h / 90 °C
View Scheme
参考文献
Sunduru, Naresh; Gupta, Leena; Chauhan, Kuldeep; Mishra, Nripendra N.; Shukla, Praveen K.; Chauhan, Prem M.S.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1232 - 1244
