1-(4,6-二甲基吡啶-2-基)-1-[2-(二(丙-2-基)氨基)乙基]-3,3-二甲基脲合成路线 （共 4 条）
反应条件
1: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, a) 75 deg C, 2 h, b) 90 deg C, 3 h
2: 6N HCl / 5 h / Heating
3: 1.) n-BuLi / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 2 h
View Scheme
参考文献
Bolhofer; Deana; Habecker; Hoffman; Gould; Pietruszkiewicz; Prugh; Torchiana; Cragoe Jr.; Hirschmann
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 538 - 544
反应条件
1: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, a) 75 deg C, 2 h, b) 90 deg C, 3 h
2: 6N HCl / 5 h / Heating
3: 1.) n-BuLi / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 2 h
View Scheme
参考文献
Bolhofer; Deana; Habecker; Hoffman; Gould; Pietruszkiewicz; Prugh; Torchiana; Cragoe Jr.; Hirschmann
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 538 - 544
反应条件
1: 6N HCl / 5 h / Heating
2: 1.) n-BuLi / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 2 h
View Scheme
参考文献
Bolhofer; Deana; Habecker; Hoffman; Gould; Pietruszkiewicz; Prugh; Torchiana; Cragoe Jr.; Hirschmann
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 538 - 544
反应条件
n-butyllithium
1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 2 h; Multistep reaction;
参考文献
Bolhofer; Deana; Habecker; Hoffman; Gould; Pietruszkiewicz; Prugh; Torchiana; Cragoe Jr.; Hirschmann
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 538 - 544
