4-溴-2-氯-6-甲基苯酚合成路线 （共 8 条）
反应条件
benzyltrimethylammonium bromide dibromide in methanol; dichloromethane 5 h; Ambient temperature;
参考文献
Heterocycles, , vol. 36, # 7 p. 1483 - 1488
反应条件
chlorine; acetic acid
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 38, p. 328
反应条件
palladium on activated charcoal; cyclohexane; benzene Hydrogenolyse unter Zusatz von Natriumacetat;
参考文献
Dow Chem. Co.
Patent: US2725402 , 1951 ;
反应条件
chromic acid; acetic acid
参考文献
Claus; Jackson
Journal fuer Praktische Chemie (Leipzig), 1888 , vol. <2> 38, p. 328
反应条件
1: K2CO3 / acetone / 4 h / Heating
2: 1.) t-BuLi, 2.) Bu3SnCl, 3.) Pd(PPh3)2Cl2
3: 99 percent / KNH2 / liquid ammonia / 3 h / -33 °C
View Scheme
参考文献
Iwao, Masatomo; Takehara, Hirokazu; Furukawa, Sunao; Watanabe, Mitsuaki
Heterocycles, 1993 , vol. 36, # 7 p. 1483 - 1488
反应条件
1: 4-bromo-2-chloro-6-methyl-phenol With potassium carbonate in N,N-dimethyl-formamide
0.0166667 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C;
参考文献
ASTRAZENECA AB; HOLENZ, Joerg; KARLSTROeM, Sofia; KIHLSTROeM, Jacob; KOLMODIN, Karin; LINDSTROeM, Johan; RAKOS, Laszlo; ROTTICCI, Didier; SWAHN, Britt-Marie; VON BERG, Stefan
Patent: WO2011/2409 A1, 2011 ;
Location in patent: Page/Page column 32 ;
WO 2011/002409 A1
反应条件
dimethyl sulfate in acetone
参考文献
Pfizer Inc.
Patent: US4476307 A1, 1984 ;
参考文献
Sarges, Reinhard; Howard, Harry R.; Koe, B. Kenneth; Weissman, Albert
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 437 - 444
