1-(1,2-苯异噁唑-3-基)乙酮合成路线 （共 8 条）
反应条件
1: in tetrahydrofuran
T=-78°C; 3 h; Inert atmosphere;
2: With ammonium chloride in tetrahydrofuran; water
T=-78 - 20°C;
参考文献
Murai, Kenichi; Miyazaki, Shuji; Fujioka, Hiromichi
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3746 - 3749
反应条件
sodium chloride; sulfuric acid; sodium hydrogencarbonate in diethyl ether; hexane; water
参考文献
Novartis Corporation
Patent: US5786374 A1, 1998 ;
反应条件
in tetrahydrofuran; diethyl ether
T=0 - 20°C; 22 h; Inert atmosphere;
参考文献
SANOFI-AVENTIS
Patent: US2011/65727 A1, 2011 ;
Location in patent: Page/Page column 18 ;
反应条件
boron trifluoride diethyl etherate; water; mercury(II) oxide in tetrahydrofuran
16 h; Ambient temperature;
参考文献
Yamamori, Teruo; Hiramatsu, Yoshiharu; Adachi, Ikuo
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 347 - 350
反应条件
2: 88.9 percent / KOH / ethanol / 20 h / Heating
3: 93.1 percent / mercuric oxide, H2O, BF3 etherate / tetrahydrofuran / 16 h / Ambient temperature
View Scheme
参考文献
Yamamori, Teruo; Hiramatsu, Yoshiharu; Adachi, Ikuo
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 347 - 350
反应条件
1: 88.9 percent / KOH / ethanol / 20 h / Heating
2: 93.1 percent / mercuric oxide, H2O, BF3 etherate / tetrahydrofuran / 16 h / Ambient temperature
View Scheme
参考文献
Yamamori, Teruo; Hiramatsu, Yoshiharu; Adachi, Ikuo
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 347 - 350
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / tetrahydrofuran / 20 h / 20 °C
2: diethyl ether; tetrahydrofuran / 22 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
SANOFI-AVENTIS
Patent: US2011/65727 A1, 2011 ;
反应条件
1.1: sulfuric acid / 48 h / 65 °C
2.1: tetrahydrofuran / 3 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C
View Scheme
参考文献
Murai, Kenichi; Miyazaki, Shuji; Fujioka, Hiromichi
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3746 - 3749
