pyridine-2-carboxylic acid, Ag(II) salt in water; benzene Ambient temperature;

1: 1.) POCl3 / 1.) r.t. 30 min 2.) r.t. 15 h then 50-60 deg C 9h 2: 80 percent / NaOH, TEBA / tetrahydrofuran / 5 h / Ambient temperature 3: 67 percent / silver(II) dipicolinate / benzene; H2O / Ambient temperature View Scheme

1: 80 percent / NaOH, TEBA / tetrahydrofuran / 5 h / Ambient temperature 2: 67 percent / silver(II) dipicolinate / benzene; H2O / Ambient temperature View Scheme