4-甲基四氢-2H-吡喃-4-醇合成路线 (共 15 条)
反应条件
methylmagnesium bromide in diethyl ether
参考文献
Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P. V. K. Suresh; Scola, Paul Michael
Patent: US2013/115190 A1, 2013 ;
Location in patent: Page/Page column ;
反应条件
in tetrahydrofuran; diethyl ether T=0 - 20°C; 2 h;
参考文献
WO2005/42533 A2, ;
Page/Page column 52 ;
WO 2005/042533 A2
反应条件
dihydrogen peroxide T=50 - 60°C; 24 h;
参考文献
Arakelyan, A. S.; Dvoryanchikov, A. I.; Gevorkyan, A. A.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 11 p. 2047 - 2050
Zhurnal Organicheskoi Khimii, 1986 , vol. 23, # 11 p. 2323 - 2326
反应条件
magnesium 1.) ether 2.) ether, 16 h; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 43, # 20 p. 4699 - 4724
反应条件
water T=25°C; various temperature; Product distributionEquilibrium constant;
参考文献
Romanov, N. A.; Kantor, E. A.; Karakhanov, R. A.; Rakhmankulov, D. L.
J. Appl. Chem. USSR (Engl. Transl.), 1983 , vol. 56, # 2 p. 333 - 337,316 - 319
反应条件
KU-2 cation-exchange resin in cyclohexane T=60 - 120°C; other catalysts (H2SO4, p-toluenesulfonic acid, BF3*O(C2H5)2, SnCl2, ZnCl2), other solvent (toluene), influence of temp. and time; Product distribution;
参考文献
Romanov, N. A.; Kantor, E. A.; Musavirov, R. S.; Karakhanov, R. A.; Rakhmankulov, D. L.
J. Appl. Chem. USSR (Engl. Transl.), 1980 , vol. 53, # 9 p. 2140 - 2143,1602 - 1605
反应条件
sulfuric acid T=40°C; Rate constant;
参考文献
Russian Journal of Applied Chemistry, , vol. 71, # 8 p. 1479 - 1481
参考文献
Organic Magnetic Resonance, , vol. 21, # 2 p. 94 - 107
反应条件
sulfuric acid T=120°C; 3 h; various catalyst, various temperature, various time, extent of conversion, solvent cyclohexane; Product distribution;
参考文献
J. Appl. Chem. USSR (Engl. Transl.), , vol. 56, # 2 p. 333 - 337,316 - 319
反应条件
potassium hydrogensulfate
T=140 - 150°C; 1 h; distillation;
参考文献
Booth, Harold; Kheidhair, Kheidhair A.; Readshaw, Simon A.
Tetrahedron, 1987 , vol. 43, # 20 p. 4699 - 4724