3-羟基-5-(4-(甲基磺酰基)苯氧基)苯甲酸甲酯合成路线 （共 5 条）
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran
4 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/121110 A1, 2005 ;
Location in patent: Page/Page column 89 ;
WO 2005/121110 A1
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=180°C; 3 h;
参考文献
Park, Kaapjoo; Lee, Byoung Moon; Hyun, Kwan Hoon; Lee, Dong Hoon; Choi, Hyun Ho; Kim, Hyunmi; Chong, Wonee; Kim, Kyeong Bae; Nam, Su Youn
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2280 - 2293
反应条件
trifluoroacetic acid in dichloromethane
T=0 - 20°C; 4 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1600442 A1, 2005 ;
Location in patent: Page/Page column 91 ;
反应条件
1: 3,5-dihydroxybenzoic acid methyl ester With potassium carbonate in N,N-dimethyl-formamide
T=120°C; 2 h;
2: 1-fluoro-4-(methylsulfonyl)benzene in N,N-dimethyl-formamide
T=120°C; 24 h; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9465 A1, 2008 ;
Location in patent: Page/Page column 78 ;
US 20080009465 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=120°C; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9465 A1, 2008 ;
Location in patent: Page/Page column 51 ;
US 20080009465 A1
