6-苯基-2,3-二氢咪唑[2,1-B] 噻唑-5-甲醛合成路线 （共 7 条）
反应条件
N-(chloromethylene)-N-methylmethanaminium chloride in pyridine; chloroform 24 h;
参考文献
Andreani; Rambaldi; Bonazzi
Farmaco, Edizione Scientifica, 1980 , vol. 35, # 7 p. 573 - 580
反应条件
1: 1.) ethanol, reflux, 15 h; 2.) ether, 24 h 2: 22 percent / SeO2 / dioxane / 8 h View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 35, # 7 p. 573 - 580
反应条件
in ethanol; water 0.166667 h; Heating;
参考文献
Andreani; Rambaldi; Mascellani; Rugarli
European Journal of Medicinal Chemistry, 1987 , vol. 22, # 1 p. 19 - 22
反应条件
sodium tetrahydroborate in methanol
1.) 3 h 15 min, r.t; 2.) 1 h, reflux;
参考文献
Andreani, A.; Bonazzi, D.; Rambaldi, M.
Farmaco, Edizione Scientifica, 1980 , vol. 35, # 11 p. 896 - 901
反应条件
ammonium hydroxide; hydroxylamine hydrochloride in ethanol
0.166667 h; Heating; Yield given;
参考文献
Andreani; Bonazzi; Rambaldi; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 3 p. 271 - 274
反应条件
1: aq. hydroxylamine hydrochloride, 32 percent NH4OH / ethanol / 0.17 h / Heating
2: SeO2 / CHCl3; dimethylformamide / 4 h / Heating
View Scheme
参考文献
Andreani; Bonazzi; Rambaldi; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 3 p. 271 - 274
反应条件
1: aq. hydroxylamine hydrochloride, 32 percent NH4OH / ethanol / 0.17 h / Heating
2: SeO2 / CHCl3; dimethylformamide / 4 h / Heating
3: 1.) conc. H2SO4; 2.) 32 percent NH4OH / 1.) 40 deg C, 2 h; 2.) ice
View Scheme
参考文献
Andreani; Bonazzi; Rambaldi; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 3 p. 271 - 274
