5-(N-叔丁氧羰基氨基)-1-戊醇合成路线 （共 23 条）
反应条件
1: triethylamine / toluene / 0.08 h / 0 °C
2: NaN3 / tetrabutylammonium bromide / toluene; H2O / 3 h / 60 °C
3: 95 percent / H2, CHCl3 / Pd-C / methanol / 1 h / 1551.4 Torr
View Scheme
参考文献
Mattingly, Phillip G.
Synthesis, 1990 , p. 366 - 368
反应条件
1: Mitsunobu reagent (azodicarboxylate, triphenylphosphine)
2: HCl / ethyl acetate
View Scheme
参考文献
Kunieda; Ishizuka; Hirobe
Chemical and pharmaceutical bulletin, 1983 , vol. 31, # 9 p. 3360 - 3362
反应条件
1: 78 percent / PPh3, CBr4 / tetrahydrofuran / Ambient temperature; 1.) 2 h, 2.) stirring overnight
2: 62 percent / KI, K2CO3 / acetone / 24 h / Heating
3: 92 percent / CF3COOH / 0.25 h / Ambient temperature
4: 95.6 percent / Et3N / acetonitrile / 2.5 h / Ambient temperature
5: tetrahydrofuran; H2O / 2 h
6: H2 / 5percent Pd/C / tetrahydrofuran; H2O / 3 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Lee; Miller
Journal of Organic Chemistry, 1983 , vol. 48, p. 24
