4-(N-叔丁氧羰基氨基)-1-丁醇合成路线 （共 21 条）
反应条件
in tetrahydrofuran T=20°C; 3 h;
参考文献
WO2006/113837 A2, ;
Page/Page column 78 ;
WO 2006/113837 A2
反应条件
Cp*RuCl{(C6H5)2P-(CH2)2NH2-κ2-P,N}; potassium tert-butylate; hydrogen in tert-butyl alcohol T=80°C; P=22502.3 Torr; 36 h; Autoclave;
参考文献
Angewandte Chemie - International Edition, , vol. 48, # 7 p. 1324 - 1327
反应条件
in dichloromethane T=0 - 20°C; 2.5 h;
参考文献
Beilstein Journal of Organic Chemistry, , vol. 10, p. 369 - 383
反应条件
1: With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran T=0°C; 0.333333 h; 2: With sodium tetrahydroborate in tetrahydrofuran; methanol T=20°C; 0.5 h; Further stages.;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 16, # 3 p. 1376 - 1392
反应条件
boron trifluoride diethyl etherate; diisobutylaluminium hydride in hexane; dichloromethane T=-78°C; 0.75 h;
参考文献
Chemistry Letters, , p. 815 - 818
反应条件
Cp*RuCl{(C6H5)2P-(CH2)2NH2-κ2-P,N}; potassium tert-butylate; hydrogen T=80°C; P=22502.3 Torr; Autoclave;
参考文献
Angewandte Chemie - International Edition, , vol. 48, # 7 p. 1324 - 1327
反应条件
Cp*RuCl{(C6H5)2P-(CH2)2NH2-κ2-P,N}; potassium tert-butylate; hydrogen T=80°C; P=22502.3 Torr; Autoclave;
参考文献
Angewandte Chemie - International Edition, , vol. 48, # 7 p. 1324 - 1327
反应条件
1: triethylamine / toluene / 0.08 h / 0 °C 2: NaN3 / tetrabutylammonium bromide / toluene; H2O / 3 h / 60 °C 3: 100 percent / H2, CHCl3 / Pd-C / methanol / 1 h / 1551.4 Torr View Scheme
参考文献
Mattingly, Phillip G.
Synthesis, 1990 , p. 366 - 368
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane T=20°C; 5 h;
参考文献
Niida, Ayumu; Tanigaki, Hiroaki; Inokuchi, Eriko; Sasaki, Yoshikazu; Oishi, Shinya; Ohno, Hiroaki; Tamamura, Hirokazu; Wang, Zixuan; Peiper, Stephen C.; Kitaura, Kazuo; Otaka, Akira; Fujii, Nobutaka
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3942 - 3951
反应条件
methanesulfonyl chloride; triethylamine in DCM
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/71396 A2, 2007 ;
Location in patent: Page/Page column 134 ;
WO 2007/071396 A2
