2,6-二甲基-1H-吡啶-4-酮合成路线 （共 6 条）
反应条件
phosphorus pentachloride; trichlorophosphate T=140°C;
参考文献
Conrad; Epstein
Chemische Berichte, 1887 , vol. 20, p. 164
反应条件
sulfuric acid; nitric acid 2 h; Heating;
参考文献
Reich; Fabio; Lee; Kuck; Testa
Journal of Medicinal Chemistry, 1989 , vol. 32, # 11 p. 2474 - 2485
反应条件
durch Zinkstaub-Destillation;
参考文献
Haitinger
Chemische Berichte, 1885 , vol. 18, p. 452
Monatshefte fuer Chemie, 1885 , vol. 6, p. 104
反应条件
sulfuric acid; nitric acid
参考文献
Hall; Collie
Journal of the Chemical Society, 1898 , vol. 73, p. 238
反应条件
1: 75 percent / 30 percent SO3/H2SO4, HNO3 / 72 h / Ambient temperature 2: 65 percent / POCl3 / 10 h / 100 °C View Scheme
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Ishibe, Noriko; Sawada, Masae; Sakuma, Yuri; Hashimoto, Masaharu; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 22 p. 4408 - 4420
反应条件
N-chloro-succinimide in methanol; dichloromethane
T=20°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/94799 A2, 2006 ;
Location in patent: Page/Page column 56 ;
