(2-氧代-1,3-噁唑烷-3-基)乙酸合成路线 （共 3 条）
反应条件
hydrogenchloride in water
T=20°C;
参考文献
AGIOS PHARMACEUTICALS, INC.; Popovici-Muller, Janeta; SAUNDERS, Jeffrey, O.; SALITURO, Francesco, G.; CAI, Zhenwei; YAN, Shunqi; ZHOU, Ding
Patent: WO2013/107405 A1, 2013 ;
Location in patent: Page/Page column 66 ;
反应条件
1: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; sodium bromide in water; acetone
T=0°C; 0.166667 h;
2: With trichloroisocyanuric acid in water; acetone
T=0 - 25°C; 12 h;
3: With hydrogenchloride in water
pH=~ 2;
参考文献
ANORMED INC.
Patent: WO2006/138350 A2, 2006 ;
Location in patent: Page/Page column 82 ;
WO 2006/138350 A2
反应条件
sodium hydroxide in tetrahydrofuran
T=20°C;
参考文献
Eckert,H.; Ugi,I.
Liebigs Annalen der Chemie, 1979 , p. 278 - 295
