pyridine in dichloromethane T=-78°C; 1 h;

1: hexadecanoic acid With 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane 0.0833333 h; Inert atmosphere; 2: 2,3-epoxy-propanol in dichloromethane T=20°C; Inert atmosphereCooling;

pyridine T=20°C; Schotten-Baumann reaction;

tetraethylammonium iodide 0.416667 h; Heating;

Novozyme 435 T=70°C; 24 h; Enzymatic reaction;

potassium acetate in various solvent(s) 42 h; Heating;

1: KOAc / various solvent(s) / 42 h / Heating 2: 0.21 g / DMAP / CHCl3 / 42 h / Ambient temperature View Scheme

potassium acetate in various solvent(s) 42 h; Heating;