2-甲基-6-苯基-4(1h)-吡啶酮合成路线 （共 9 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol
T=50°C; 12 h;
参考文献
Eiden, Fritz; Patzelt, Gertrud
Archiv der Pharmazie (Weinheim, Germany), 1986 , vol. 319, # 3 p. 242 - 251
反应条件
1: (Z)-4-(phenylamino)-3-penten-2-one With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: benzonitrile in tetrahydrofuran; hexane
T=-78 - -50°C; 0.333333 h;
3: With hydrogenchloride; sodium hydroxide
more than 3 stages;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/44217 A2, 2008 ;
Location in patent: Page/Page column 77-78 ;
WO 2008/044217 A2
反应条件
1.1: toluene-4-sulfonic acid / toluene / 3.5 h / Reflux
2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / 0.42 h / -78 °C
2.2: 1.5 h / -78 - -56 °C
View Scheme
参考文献
Caroff, Eva; Hilpert, Kurt; Hubler, Francis; Meyer, Emmanuel; Renneberg, Dorte
Patent: US2011/46089 A1, 2011 ;
反应条件
hydrogenchloride in methanol
0.75 h; Ambient temperature; Yield given;
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Cimarelli, Cristina; Dalpozzo, Renato; De Munno, Giovanni; et al.
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 6020 - 6025
反应条件
2: HCl / methanol / 0.75 h / Ambient temperature
View Scheme
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Cimarelli, Cristina; Dalpozzo, Renato; De Munno, Giovanni; et al.
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 6020 - 6025
反应条件
2: HCl / methanol / 0.75 h / Ambient temperature
View Scheme
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Cimarelli, Cristina; Dalpozzo, Renato; De Munno, Giovanni; et al.
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 6020 - 6025
反应条件
1: 1.) LDA / 1.) THF, hexane, -90 deg C, 30 min, 2.) THF, hexane, from -90 deg C to RT, 1 h
2: 32 percent / Mo(CO)6, H2O / 1.5 h / Heating
View Scheme
参考文献
Nitta, Makoto; Higuchi, Takanobu
Heterocycles, 1994 , vol. 38, # 4 p. 853 - 858
反应条件
1: 1.) LDA / 1.) THF, hexane, -90 deg C, 30 min, 2.) THF, hexane, from -90 deg C to RT, 1 h
2: 32 percent / Mo(CO)6, H2O / 1.5 h / Heating
View Scheme
参考文献
Nitta, Makoto; Higuchi, Takanobu
Heterocycles, 1994 , vol. 38, # 4 p. 853 - 858
反应条件
1.1: trichlorophosphate / N,N-dimethyl-formamide / 4 h / Reflux
2.1: selenium(IV) oxide / 1,4-dioxane / 4.5 h / 0 °C / Reflux
2.2: Reflux
View Scheme
参考文献
Caroff, Eva; Hilpert, Kurt; Hubler, Francis; Meyer, Emmanuel; Renneberg, Dorte
Patent: US2011/46089 A1, 2011 ;
