1: With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in DMF (N,N-dimethyl-formamide); water 0.05 h; 2: With hydrogenchloride in DMF (N,N-dimethyl-formamide); water
potassium hydroxide in isopropyl alcohol T=55 - 60°C; Yield given;
参考文献
Medwid, Jeffrey B.; Paul, Rolf; Baker, Jannie S.; Brockman, John A.; Du, Mila T.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1230 - 1241
Soborowskii; Baina
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 1142; engl.Ausg. S.1113
Full Text Show Details
Hine; Porter
Journal of the American Chemical Society, 1957 , vol. 79, p. 5493,5494,5495
Soborowskii; Baina
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 1142; engl.Ausg. S.1113
Full Text Show Details
Hine; Porter
Journal of the American Chemical Society, 1957 , vol. 79, p. 5493,5494,5495