1: 4-Bromo-2-fluorobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 0.5 h; 2: dimethyl amine With triethylamine in dichloromethane T=20°C; 0.166667 h; 3: With hydrogenchloride in dichloromethane; water T=20°C;

benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in acetonitrile T=70°C; 2 h;

caesium carbonate in tetrahydrofuran

1: thionyl chloride / 12 h / 20 °C 2: caesium carbonate / tetrahydrofuran View Scheme

暂无反应条件数据

1: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane in 2-methyl tetrahydrofuran T=80°C; 15 h; 2: With water; sodium hydroxide in 2-methyl tetrahydrofuran 3: With hydrogenchloride; sodium periodate in 2-methyl tetrahydrofuran; water T=20°C; 15 h;

1: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 2-methyl tetrahydrofuran T=80°C; 15 h; 2: With water; sodium hydroxide in 2-methyl tetrahydrofuran 3: With hydrogenchloride in 2-methyl tetrahydrofuran; water T=0°C; pH=1.5;